Current Issue : October - December Volume : 2015 Issue Number : 4 Articles : 6 Articles
Skin exposure to acute or repetitive ultraviolet light induces major skin risks, an efficient photoprotection is thus required for both UVB and UVA radiation. The aim of this work is to formulate and evaluate oleogels as cosmetic bases containing 2% w/w of the liposoluble sunscreening agent Bemotrizinol aiming to obtain an effective photoprotective, photostable and water resistant product thereby increasing patient compliance. A factorial design (3.23) was adopted to study the effect of four independent variables namely; gelling agent type and concentration, stabilizer type and concentration on thermostability and rheological properties of the prepared oleogels using Design-Expert® software. The selected Bemotrizinol oleogel formulae were further evaluated regarding in-vitro SPF, ex-vivo permeation, photostability and water resistant tests. Both type and concentration of the gelling agent affected the stability and rheological characteristics of the different prepared oleogels. The two optimized oleogels F8 and F12 showed convenient SPF values of 13.25±0.03 and 16.85±2.75 respectively, low skin permeation (< 10% at Q8hrs) with 90-100% SPF retention after 80 minutes [min] immersion in water. Photostability test revealed a higher area under curve index (AUCI) of ≥ 0.80. Oleogels could be promising as cosmetic bases for the liposoluble sunscreening agent bemotrizinol useful in the prevention of skin sunburns and photoaging....
Lipid nanoparticles are an alternative carrier system to liposomes and emulsions. This review paper focuses on lipid nanoparticles for cosmetic and topical application. Production of lipid nanoparticles and final products containing lipid nanoparticles is feasible by well-established production methods. Lipid nanoparticle exhibit many features for topical application of cosmetics and pharmaceutics, i.e. controlled release of actives, Physical and chemical stability of active pharmaceutical ingredients, drug targeting, occlusion, film formation and associated with it penetration enhancement and increase of skin hydration. Due to the production of lipid nanoparticles from physiological and/or biodegradable lipids, this carrier system exhibits an excellent tolerability. The lipid nanoparticles are a “nanosafe” carrier. Furthermore, an overview of the cosmetic products currently on the market is given and the improvement of the benefit/risk ratio of the topical therapy is shown....
Natural ingredients have been used for centuries for skin care purposes.\nNowadays, they are becoming more prevalent in formulations, due to consumers� concerns\nabout synthetic ingredients/chemical substances. The main benefits reported for plant\nextracts, used in skin care, include antioxidant and antimicrobial activities and tyrosinase\ninhibition effect. In this review, some examples of plants from Portuguese flora, whose\nextracts have shown good properties for skin care are presented. However, despite the known\nproperties of plant extracts, few studies reported the development of formulations with them.\nMore work in this field can be accomplished to meet consumer demand....
Dermatologic physiology and aesthetics are profoundly connected.\nInflammatory stimuli abound in the environment, and have the potential to impact both the\nphysiology and aesthetics of the integument. Inflammation results in a compromised\nepidermal barrier, impaired moisture retention, erythema, scale and pigment alteration. The\nadvent of nanotechnology has introduced a variety of new approaches to preserving skin\ncosmesis in the face of inflammation. In this article, we review the architecture and\nphysiology of the epidermal barrier, describe the pathological and aesthetic effects of\ninflammation, and report recent advances in the development of nanomaterials to offset the\naesthetic impact of inflammation....
The impact of increasing age on body odor has become an important issue as\nour understanding of underlying skin changes in older people has increased. Therefore,\ncosmetic skin products especially for the needs of the elderly are of growing importance.\nThis randomized single-blind crossover study assessed the deodorizing efficacy of two\ncosmetic products with different pH values on the age-specific odor of an elderly female\nsubject panel (60 years). The two test products, adjusted to pH 4.0 and pH 5.8 were\napplied to the axillae once daily for three consecutive days after standardized washing of\nthe axillae. The untreated axilla was used as a control. Six odor judges evaluated the\nefficacy of both products. Additionally, bactericidal and fungicidal activity was\ninvestigated with in vitro microbiologic tests. The pH 4.0 water in oil (W/O) emulsion\nsignificantly reduced axillary malodor in 44 elderly subjects at 8 and 24 h after treatment,\ncompared with controls (untreated axillae) (p < 0.001 after 8 and 24 h), whereas pH 5.8\nemulsion had no effect (p = 0.441 after 8 h; p = 0.425 after 24 h). Moreover, the pH 4.0\nemulsion reduced axillary malodor at 8 and 24 h after treatment, compared with the pH 5.8\nemulsion just narrowly missing statistical significance (p = 0.078 after 8 h; p = 0.053 after\n24 h). Microbiologic in vitro tests showed that the pH 4.0 emulsion reduced the levels of\nodor-producing bacteria S. epidermidis and C. minutissimum after 1 h (2.98 log and\n4.25 log). After 24 h, levels of S. aureus (>5.50 log), P. acnes (>5.30 log) and E. coli (>5.46 log) were further reduced whereas no effect was observed for pH 5.8.\nA pH 4.0 emulsion significantly reduced axillary malodor for up to 24 h after application\nin females aged at least 60 years. This reduction in malodor is very likely due to a\nreduction of odor-producing bacteria....
The proper condition of hydrolipid mantle and the stratum corneum intercellular\nmatrix determines effective protection against transepidermal water loss (TEWL). Some\nchemicals, improper use of cosmetics, poor hygiene, old age and some diseases causes\ndisorder in the mentioned structures and leads to TEWL increase. The aim of this study\nwas to obtain the optimal formulation composition of an oiling bath cosmetic based on\nrapeseed phospholipids and vegetable oil with high content of polyunsaturated fatty acids.\nIn this work, the composition of oiling bath form was calculated and the degree of oil\ndispersion after mixing the bath preparation with water was selected as the objective\nfunction in the optimizing procedure. The full factorial design 23 in the study was used.\nThe concentrations of rapeseed lecithin ethanol soluble fraction (LESF), alcohol (E) and\nnon-ionic emulsifier (P) were optimized. Based on the calculations from our results,\nthe optimal composition of oiling bath cosmetic was: L (LESF) 5.0 g, E (anhydrous\nethanol) 20.0 g and P (Polysorbate 85) 1.5 g. The optimization procedure used in the study\nOPEN ACCESS allowed to obtain the oiling bath cosmetic which gives above 60% higher emulsion\ndispersion degree 5.001 Ã?â?? 105 cm1 compared to the initial formulation composition with\nthe 3.096 Ã?â?? 105 cm1....
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